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M94A0178.TXT
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1994-10-08
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Document 0178
DOCN M94A0178
TI Alkaline phosphatase band-10 fraction as a possible surrogate marker for
human immunodeficiency virus type 1 infection in children [see comments]
DT 9412
AU Murthy VV; Calvelli TA; Rubinstein A; Karmen A; Department of Laboratory
Medicine, Albert Einstein College of; Medicine, Bronx, NY 10461.
SO Arch Pathol Lab Med. 1994 Sep;118(9):873-7. Unique Identifier : AIDSLINE
MED/94361595
CM Comment in: Arch Pathol Lab Med 1994 Sep;118(9):868-9
AB We report the utility of a possible lymphocyte fraction of alkaline
phosphatase (ALP band-10) activity in serum to predict human
immunodeficiency virus type 1 (HIV-1) infection in children born to
HIV-1-seropositive mothers. The presence of ALP band 10 in serum
consistently correlated with HIV-1 infection status as judged by
positive HIV-1 culture, two consecutive HIV-1 p24 antigen results
greater than 30 pg/mL in serum, and the subsequent confirmation of
seroconversion to HIV-1 antibody after clearance of maternal IgG
anti-HIV-1 antibody ascertained between 15 to 24 months post partum.
Infection with HIV-1 was correctly identified in 31 samples from 18
patients ranging in age between 0.1 to 10 years; the absence of similar
infection was noted in 14 samples from nine patients who served as
controls and whose serum samples did not exhibit ALP band-10 activity.
This ability of serum ALP band-10 activity to predict HIV-1 infection
status in children as young as 2 months may be useful as a surrogate
marker for early identification of HIV-1 infection in infants born to
HIV-1-seropositive women long before the clearance of maternal
anti-HIV-1 antibodies can be ascertained.
DE Alkaline Phosphatase/*BLOOD Biological Markers/BLOOD Child Child,
Preschool Human HIV Infections/*ENZYMOLOGY *HIV-1 Infant
Isoenzymes/*BLOOD JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).